Departments of Breast and Endocrine Surgery, Kumamoto City Hospital, Kumamoto City, Japan. nishimura.reiki @ cityhosp-kumamoto.jp
Oncology. 2013;85(2):100-10. doi: 10.1159/000353099. Epub 2013 Jul 17.
Breast cancer is associated with a relatively good prognosis. Prognostic factors examined to date are related to early recurrence while those related to late recurrence and their countermeasures remain unclear. Therefore, we examined the factors related to late recurrence.
From January 1980 to August 2012, 4,774 patients who underwent primary treatment and estrogen (ER) and progesterone receptor (PgR) assessment were enrolled in this study. The patients were divided into two groups, those with a follow-up period <10 years and those without any recurrence at 10 years but who continued follow-up examinations. Recurrence occurred in 711 patients followed up for <10 years and in 51 patients for ≥10 years.
The overall 10-year cumulative disease-free survival rate was 79.5%, and the recurrence rate at ≥10 years was 5.8%. A multivariate analysis revealed that the factors related to late recurrence were PgR positivity and positive nodes. This result differed from that for early recurrence in terms of ER/PgR, Ki-67 index and p53 overexpression.
PgR positivity and lymph node metastases significantly correlated with late recurrence. Therefore, it is important to evaluate appropriate measures such as treatment period and treatment regimen for hormone-sensitive patients.
乳腺癌的预后相对较好。迄今为止，检查到的预后因素与早期复发有关，而与晚期复发相关的因素及其对策尚不清楚。因此，我们检查了与晚期复发相关的因素。
本研究纳入了 1980 年 1 月至 2012 年 8 月期间接受初次治疗和雌激素（ER）及孕激素受体（PgR）评估的 4774 例患者。患者分为两组，一组随访时间<10 年，另一组随访 10 年无任何复发，但继续进行随访检查。在随访时间<10 年的 711 例患者中出现了复发，在随访时间≥10 年的 51 例患者中出现了复发。
总体 10 年无病生存率为 79.5%，随访≥10 年的复发率为 5.8%。多因素分析显示，与晚期复发相关的因素是 PgR 阳性和阳性淋巴结。这一结果与 ER/PgR、Ki-67 指数和 p53 过表达的早期复发因素不同。
PgR 阳性和淋巴结转移与晚期复发显著相关。因此，对于激素敏感的患者，评估适当的治疗期限和治疗方案非常重要。
