Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Freiburg, Germany; Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany.
Department of Radiology, University Hospital Bonn, Bonn, Germany.
Alzheimers Dement. 2014 Jan;10(1):99-108. doi: 10.1016/j.jalz.2013.05.1764. Epub 2013 Jul 15.
Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI.
We used a discriminative function (a support vector machine) trained on an independent data set of 226 healthy control subjects and 191 patients with probable Alzheimer's disease (AD) dementia to characterize the baseline gray matter patterns of 24 individuals with SMI and 53 control subjects. We tested for associations of these gray matter patterns with SMI presence, cognitive performance at baseline, and cognitive decline at follow-up.
Individuals with SMI showed greater similarity to an AD gray matter pattern compared with control subjects without SMI. In addition, episodic memory decline was associated with an AD gray matter pattern in the SMI group.
Our results indicate a link between the gray matter atrophy pattern of patients with AD and the presence of SMI. Furthermore, multivariate pattern recognition approaches seem to be a sensitive method for identifying subtle brain changes that correspond to future memory decline in SMI.
有主观记忆损伤（SMI）的个体报告记忆恶化，但认知测试无损伤。尽管认知表现正常，他们的认知衰退风险可能比没有 SMI 的个体更高。
我们使用基于 226 名健康对照者和 191 名可能患有阿尔茨海默病（AD）痴呆的患者的独立数据集进行训练的判别函数（支持向量机），来描述 24 名 SMI 患者和 53 名对照者的基线灰质模式。我们测试了这些灰质模式与 SMI 存在、基线认知表现和随访时认知下降的相关性。
与没有 SMI 的对照组相比，SMI 个体的大脑灰质模式与 AD 更为相似。此外，在 SMI 组中，情景记忆下降与 AD 灰质模式有关。
我们的结果表明 AD 患者的灰质萎缩模式与 SMI 的存在之间存在联系。此外，多元模式识别方法似乎是一种敏感的方法，可以识别与 SMI 未来记忆下降相对应的细微脑变化。
