Selinger C P
Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, UK -
Minerva Gastroenterol Dietol. 2013 Sep;59(3):285-97.
Inflammatory bowel disease (IBD) often occurs in women of childbearing age and requires complex treatment decision. IBD can have profound influences on fertility, the course of a pregnancy, child birth and lactation. Many women with IBD remain voluntarily childless and patient knowledge of pregnancy related issues is generally poor, which can lead to negative views regarding IBD treatments. To achieve good clinical outcomes for mother and infant a balance has to be struck between the risks of any IBD treatment and the risks of untreated IBD. The advent of the biological age has brought another level of complexity. While more data demonstrating the safe use in pregnancy have recently emerged, effects on infants continue for up to 6 months with important implications on vaccination plans. This review discusses recent advances in the field of IBD and reproduction.
炎症性肠病（IBD）常发生于育龄女性，治疗决策复杂。IBD会对生育能力、孕期、分娩及哺乳产生深远影响。许多患有IBD的女性自愿选择不育，且患者对妊娠相关问题的了解普遍不足，这可能导致对IBD治疗产生负面看法。为了母婴获得良好的临床结局，必须在IBD任何治疗的风险与未治疗IBD的风险之间取得平衡。生物制剂时代的到来带来了另一层面的复杂性。虽然最近有更多数据表明其在孕期使用安全，但对婴儿的影响会持续长达6个月，这对疫苗接种计划有重要影响。本综述讨论了IBD与生殖领域的最新进展。
