Jutila J W, Reed N D, Isaak D D
Birth Defects Orig Artic Ser. 1975;11(1):522-7.
The central role of the thymus in immunity was assessed in nude mice. Nudes failed to reject allografts and xenografts and to respond to foreign erythrocytes but responded normally to endotoxin and pneumococcal polysaccharide. Thymus reconstitution was demonstrated in vivo and in vitro whereas reconstitution with thymic humoral factors or polyanions was not detected. Coliform overgrowth and depressed IgA levels in nudes appeared to contribute to wasting. These data emphasize the need for thymus participation in many immune phenomena.
在裸鼠中评估了胸腺在免疫中的核心作用。裸鼠无法排斥同种异体移植和异种移植，也无法对外来红细胞作出反应，但对内毒素和肺炎球菌多糖反应正常。胸腺在体内和体外均显示有重建现象，而未检测到胸腺体液因子或聚阴离子的重建作用。裸鼠中大肠菌过度生长和IgA水平降低似乎导致了消瘦。这些数据强调了胸腺参与多种免疫现象的必要性。
