Zutter M M, Gersell D J
Washington University School of Medicine, Department of Pathology, St. Louis, Missouri 63110.
Cancer. 1990 Sep 1;66(5):1002-4. doi: 10.1002/1097-0142(19900901)66:5<1002::aid-cncr2820660534>3.0.co;2-t.
Female genital tract involvement by hematologic neoplasms is uncommon and is usually associated with disseminated disease. Lymphoid neoplasms, which involve the cervix and uterus primarily, are usually of either diffuse large cell or small cleaved cell type, and rarely Burkitt's (small non-cleaved) lymphoma or granulocytic sarcoma. In this report the authors describe young woman with acute stem cell leukemia which was terminal deoxyribonucleotidyl transferase positive, and involved the bone marrow and peripheral blood. After induction of remission and a 2-year disease-free interval, she relapsed with involvement localized to the uterus and cervix. At relapse the leukemic cells expressed CD1, CD2, CD5, CD7, and CD4 or CD8, antigens of the common thymocyte compartment. The authors postulate that the T-cell antigens, known extracellular matrix receptors, may have determined the tissue infiltration: an unusual pattern of relapse.
血液系统肿瘤累及女性生殖道并不常见，通常与播散性疾病相关。主要累及宫颈和子宫的淋巴样肿瘤，通常为弥漫性大细胞型或小裂细胞型，很少为伯基特（小无裂）淋巴瘤或粒细胞肉瘤。在本报告中，作者描述了一名患有末端脱氧核糖核苷酸转移酶阳性的急性干细胞白血病的年轻女性，该疾病累及骨髓和外周血。在诱导缓解并经过2年无病期后，她复发，病变局限于子宫和宫颈。复发时，白血病细胞表达常见胸腺细胞区室的抗原CD1、CD2、CD5、CD7和CD4或CD8。作者推测，已知的细胞外基质受体T细胞抗原可能决定了组织浸润：这是一种不寻常的复发模式。
