Kazma Jamil, Johnson Cynae, Jain Nitin, Gali Vasantha Lakshmi, Young Ken H, Jazaeri Amir A
Department of Internal Medicine, American University of Beirut Medical Center, Lebanon.
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, USA.
Gynecol Oncol Rep. 2019 Aug 12;29:94-97. doi: 10.1016/j.gore.2019.08.003. eCollection 2019 Aug.
The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the end of her last cycle for which an MRI abdomen and pelvis was done and it showed the presence of an asymmetrical cervical mass. Further imaging included a PET-CT showing the presence of hypermetabolic cervical mass with left pelvic and retroperitoneal lymph node involvement. She underwent a biopsy of 3 distinct lesions in the cervix and vagina and a diagnosis of relapsed B-cell ALL was confirmed in two out of the three specimens.
宫颈作为血液系统恶性肿瘤的复发部位较为罕见。我们在此报告一例复发性B细胞急性淋巴细胞白血病/淋巴瘤（ALL），表现类似晚期宫颈癌。该患者为61岁女性，有B细胞ALL病史，曾多次复发，均局限于骨髓，并接受过多种不同的化疗方案。她在最后一个化疗周期结束后出现下腹痛，为此进行了腹部和盆腔MRI检查，结果显示宫颈有不对称肿块。进一步的影像学检查包括PET-CT，显示宫颈高代谢肿块，伴有左侧盆腔和腹膜后淋巴结受累。她接受了宫颈和阴道三个不同病变的活检，三个标本中有两个确诊为复发性B细胞ALL。
