Soltanghoraee H, Pourkeramati F, Khoddami M, Amirjannati N, Akhondi M M, Soltani A
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Andrologia. 2014 Sep;46(7):726-30. doi: 10.1111/and.12139. Epub 2013 Jul 21.
Almost all testicular germ cell tumours are proved to originate from carcinoma in situ cells. Infertility is one of the factors that increase the risk of carcinoma in situ. The reported prevalence for carcinoma in situ from different parts of the world is 0-3.7% in infertile men. This retrospective study was performed to determine the prevalence of carcinoma in situ in Iranian infertile men. We reviewed the testicular biopsies of 1153 infertile men at the pathology department of Avicenna Infertility Center. One hundred and fifty-one cases were suspicious of having carcinoma in situ. Immunohistochemical marker for placental alkaline phosphatase was employed to confirm the diagnosis of carcinoma in situ. Positive results were detected in 7 (0.6%) of 1153 cases (95% CI 0.24%-1.24%), 6 (0.94%) of which (95% CI 0.34%-2.04%) were under the age of 35 years (636 patients were in this age group). This study is the first study in Iran determining the prevalence of carcinoma in situ among the infertile Iranian men; the result is in the range of reports from other countries.
几乎所有睾丸生殖细胞肿瘤都被证明起源于原位癌细胞。不育是增加原位癌风险的因素之一。据报道，世界各地不育男性原位癌的患病率为0 - 3.7%。本回顾性研究旨在确定伊朗不育男性原位癌的患病率。我们回顾了阿维森纳不育中心病理科1153名不育男性的睾丸活检情况。151例疑似患有原位癌。采用胎盘碱性磷酸酶免疫组化标记物来确诊原位癌。在1153例病例中有7例（0.6%）检测结果呈阳性（95%可信区间0.24% - 1.24%），其中6例（0.94%）（95%可信区间0.34% - 2.04%）年龄在35岁以下（该年龄组有636名患者）。本研究是伊朗第一项确定伊朗不育男性原位癌患病率的研究；结果在其他国家的报告范围内。
