West A B, Butler M R, Fitzpatrick J, O'Brien A
J Urol. 1985 Jan;133(1):107-9. doi: 10.1016/s0022-5347(17)48810-0.
We report on 4 men attending our infertility clinic in whom seminomas developed. A review of testicular biopsies performed for investigation of subfertility in 2 patients revealed in situ and early invasive carcinoma. Infertile men have a prevalence of carcinoma in situ in the range of 1 per 100 to 200, with a high risk of progression to invasive germ cell tumor (50 per cent within 5 years of diagnosis). Biopsy is the only method of detection of the in situ lesion and, therefore, is recommended in the investigation of oligospermic and azoospermic male subjects. The surgical approach to and diagnostic sensitivity of testicular biopsy are reviewed, and the management of carcinoma in situ is discussed.
我们报告了4名在我们不孕不育诊所就诊后发生精原细胞瘤的男性。对2名因不育症接受检查而进行睾丸活检的患者进行复查时发现了原位癌和早期浸润性癌。不育男性原位癌的患病率在每100至200人中约有1例，进展为浸润性生殖细胞肿瘤的风险很高（诊断后5年内为50%）。活检是检测原位病变的唯一方法，因此，在对少精子症和无精子症男性受试者进行检查时建议采用。本文回顾了睾丸活检的手术方法和诊断敏感性，并讨论了原位癌的处理。
