Berthelsen J G, Skakkebaek N E
Scand J Urol Nephrol. 1981;15(3):165-8. doi: 10.3109/00365598109179596.
Quantitative histological studies on four testicles removed because of carcinoma in situ (CIS) were performed in order to determine the likelihood of diagnosing carcinoma in situ testis by biopsy. The CIS changes were evenly distributed in the testicles except for the parts adjacent to the epididymis, where the lesion was less frequent. In parts of the testicles where more than approximately 10% of the testicular volume contained tubules with CIS all simulated biopsies measuring 3 mm contained the lesion. The same was true for simulated biopsies measuring 1.5 mm when more than approximately 30% of testicular volume consisted of tubules with CIS. If the distribution of carcinoma in situ generally is similar to that found in the four analysed testicles there seems to be a high probability of detecting the disease by one or two testicular biopsies of 3 mm.
为了确定通过活检诊断原位癌睾丸的可能性，对因原位癌（CIS）而切除的四个睾丸进行了定量组织学研究。除了靠近附睾的部分病变较少外，原位癌的变化在睾丸中分布均匀。在睾丸中，当超过约10%的睾丸体积包含有原位癌的小管时，所有3毫米的模拟活检都包含该病变。当超过约30%的睾丸体积由有原位癌的小管组成时，1.5毫米的模拟活检也是如此。如果原位癌的分布总体上与在四个分析的睾丸中发现的相似，那么通过一两次3毫米的睾丸活检检测到该病的可能性似乎很高。
