Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.
J Integr Plant Biol. 2013 Sep;55(9):847-63. doi: 10.1111/jipb.12092.
In the past 20-30 years, developmental biologists have made tremendous progress in identifying genes required for the specification of individual cell types of an organ and in describing how they interact in genetic networks. In comparison, very little is known about the mechanisms that regulate tissue polarity and overall organ patterning. Gynoecia and fruits from members of the Brassicaceae family of flowering plants provide excellent model systems to study organ patterning and tissue specification because they become partitioned into distinct domains whose formation is determined by polarity establishment both at a cellular and whole tissue level. Interactions among key regulators of Arabidopsis gynoecium and fruit development have revealed a network of upstream transcription factor activities required for such tissue differentiation. Regulation of the plant hormone auxin is emerging as both an immediate downstream output and input of these activities, and here we aim to provide an overview of the current knowledge regarding the link between auxin and female reproductive development in plants. In this review, we will also demonstrate how available data can be exploited in a mathematical modeling approach to reveal and understand the feedback regulatory circuits that underpin the polarity establishment, necessary to guide auxin flows.
在过去的 20-30 年中，发育生物学家在确定器官中特定细胞类型所需的基因方面取得了巨大进展，并描述了它们在遗传网络中的相互作用方式。相比之下，对于调节组织极性和整体器官模式的机制知之甚少。开花植物的芸薹属科成员的雌蕊和果实为研究器官模式和组织特化提供了极好的模型系统，因为它们被分隔成不同的区域，其形成是由细胞和整个组织水平的极性建立决定的。拟南芥雌蕊和果实发育的关键调节因子之间的相互作用揭示了一个上游转录因子活性网络，这些活性是组织分化所必需的。植物激素生长素的调节作用作为这些活性的直接下游输出和输入而出现，在这里，我们旨在提供植物中生长素与雌性生殖发育之间联系的当前知识概述。在这篇综述中，我们还将展示如何利用现有数据进行数学建模方法，以揭示和理解支持极性建立的反馈调节回路，这对于指导生长素的流动是必要的。
