Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, Shanghai, China.
Clin Radiol. 2013 Oct;68(10):e532-7. doi: 10.1016/j.crad.2013.05.100. Epub 2013 Jul 18.
To investigate and characterize the effect of age on apparent diffusion coefficient (ADC) values in the normal adult pancreas using diffusion-weighted magnetic resonance imaging (DWI).
Five hundred and fifty-nine adult patients without pancreatic disease, ranging from 20-81 years of age (mean 50.9 years; 436 men, 123 women), were included in this study. Breath-hold single-shot echo-planar DWI (b-values = 0, 500 s/mm(2)) was employed to determine the ADCs across all patients. Dependency of ADCs on age was characterized using a Spearman rank-order correlation test.
Across the age spectrum, there was no significant correlation between ADC and age (p = 0.409).
The findings of the present study suggest that the effect of age on ADCs can be excluded from the diagnosis of pancreatic diseases and design of future studies using breath-hold single-shot DWI and ADCs (as calculated with b-values of 0 and 500 s/mm(2)).
使用弥散加权磁共振成像（DWI）研究并描述年龄对正常成人胰腺表观弥散系数（ADC）值的影响。
本研究纳入了 559 名无胰腺疾病的成年患者，年龄 20-81 岁（平均 50.9 岁；男 436 例，女 123 例）。对所有患者均行单次屏气 EPI DWI（b 值=0、500 s/mm²）以确定 ADC 值。采用 Spearman 秩相关检验来描述 ADC 值与年龄的相关性。
在整个年龄范围内，ADC 值与年龄之间无显著相关性（p=0.409）。
本研究结果表明，在使用单次屏气 DWI 和 ADC 值（b 值分别为 0 和 500 s/mm²）诊断胰腺疾病和设计未来研究时，可以排除年龄对 ADC 值的影响。
