Varela P, Marcos A, Ripoll S, Requejo A, Herrera P, Casas A
Departamento de Nutrición y Bromatología, I. (Nutrición), Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.
Eur J Clin Nutr. 1990 May;44(5):415-8.
Since human immunodeficiency virus (HIV) is known to lead to modifications of immune function and interrelationships among malnutrition, anergy and drug addiction have been shown, the aim of this work was to assess the nutritional status of 36 male heroin addicts under a period of detoxication (3 months). They were divided into two groups: (1) HIV negative (n = 20) and (2) HIV positive (n = 16); heights, weights and serum albumin concentration were measured and immune function was tested, using delayed hypersensitivity skin tests containing 7 antigens. No significant differences in anthropometric measurements were found between both groups, but anthropometric improvement was shown in every patient after the detoxication period. Serum albumin, often used as a classical index of malnutrition, remained within the normal values in both groups. The whole response to skin tests was depressed in both groups and no significant differences were shown between them. Therefore, these results might suggest that in spite of the apparent anthropometric recovery and the normal values of albumin, a subclinical malnutrition was indicated by the depressed immune function, which was more noticeable in the HIV-positive group.
由于已知人类免疫缺陷病毒（HIV）会导致免疫功能改变，且营养不良、无反应性与药物成瘾之间的相互关系已得到证实，因此本研究的目的是评估36名男性海洛因成瘾者在戒毒期（3个月）的营养状况。他们被分为两组：（1）HIV阴性（n = 20）和（2）HIV阳性（n = 16）；测量身高、体重和血清白蛋白浓度，并使用包含7种抗原的迟发型超敏皮肤试验检测免疫功能。两组之间的人体测量学指标没有显著差异，但戒毒期后每位患者的人体测量学指标均有改善。血清白蛋白常被用作营养不良的经典指标，两组均保持在正常范围内。两组对皮肤试验的整体反应均降低，且两组之间无显著差异。因此，这些结果可能表明，尽管人体测量学指标明显恢复且白蛋白值正常，但免疫功能降低表明存在亚临床营养不良，这在HIV阳性组中更为明显。
