Sturm A W
Department of Medical Microbiology, St. Laurentius Hospital, Roermond, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1990 Jun;9(6):381-9. doi: 10.1007/BF01979466.
To assess the impact of a restrictive antimicrobial policy, the efficacy of therapeutic and prophylactic antibiotic regimens and the susceptibility patterns of infecting bacterial microorganisms were studied during a two-month period in 1986 in inpatients in a general hospital. Twenty-eight percent of patients received antimicrobial agents, 21% as treatment and 7% as prophylaxis. In the 359 evaluable episodes of infection cure was obtained in 88% of cases with the initial therapy and in 7% after a change of drugs, but treatment failed in 5%. Of the 18 cases of failure, improvement was seen in eight although the infection persisted. Ten patients died but in seven of them the infection only partially contributed to this outcome. Ten (8%) of 127 patients receiving antimicrobial prophylaxis developed an infection but in three there was no relation to the condition for which the prophylactic regimen was originally prescribed. No changes were found in the susceptibility patterns of microorganisms.
为评估限制性抗菌政策的影响，1986年在一家综合医院对住院患者进行了为期两个月的研究，以探讨治疗性和预防性抗生素方案的疗效以及感染细菌微生物的药敏模式。28%的患者接受了抗菌药物治疗，其中21%用于治疗，7%用于预防。在359例可评估的感染病例中，88%的患者初始治疗即获治愈，7%的患者在更换药物后治愈，但5%的患者治疗失败。在18例治疗失败的病例中，8例病情有所改善，尽管感染仍持续存在。10例患者死亡，但其中7例患者的感染只是导致死亡的部分原因。127例接受抗菌预防的患者中有10例（8%）发生了感染，但其中3例与最初规定的预防方案所针对的疾病无关。微生物的药敏模式未发现变化。
