Ghoshhajra Brian B, Lee Ashley M, Engel Leif-Christopher, Celeng Csilla, Kalra Mannudeep K, Brady Thomas J, Hoffmann Udo, Westra Sjirk J, Abbara Suhny
Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Boston, MA, 02114, USA.
Pediatr Cardiol. 2014 Jan;35(1):171-9. doi: 10.1007/s00246-013-0758-5. Epub 2013 Jul 20.
Cardiac CT angiography (cCTA) has become an established method for the assessment of congenital heart disease. However, the potential harmful effects of ionizing radiation must be considered, particularly in younger, more radiosensitive patients. In this study, we sought to assess the temporal change in radiation doses from pediatric cCTA during an 8-year period at a tertiary medical center. This retrospective study included all patients ≤18 years old who were referred to electrocardiography (ECG)-gated cCTA for the assessment of congenital heart disease or inflammatory disease (Kawasaki disease) from November 2004 to September 2012. During the study period, 95 patients were scanned using 3 different scanner models-64-slice multidetector CT (64-MDCT) and first- (64-DSCT) and second-generation (128-DSCT) dual-source CT-and 3 scan protocols-retrospective ECG-gated helical scanning (RG), prospective ECG-triggered axial scanning (PT), or prospective ECG-triggered high-pitch helical scanning (HPH). Effective dose (ED) was calculated with the dose length product method with a conversion factor (k) adjusted for age. ED was then compared among scan protocols. Image quality was extracted from clinical cCTA reports when available. Overall, 94 % of scans were diagnostic (80 % for 64-slice MDCT, 93 % for 64-slice DSCT, and 97 % for 128-slice DSCT).With 128-DSCT, median ED (1.0 [range 0.6-2.0] mSv) decreased by 85.8 % and 66.8 % compared with 64-MDCT (6.8 [range 2.9-13.6] mSv) and 64-DSCT (2.9 [range 0.9-4.1] mSv), respectively. With HPH, median ED (0.9 [range 0.6-1.8] mSv) decreased by 59.4 % and 85.4 % compared with PT (2.2 [range 0.9-3.4] mSv) and RG (6.1 [range 2.5-10.6] mSv). cCTA can now be obtained at very low radiation doses in pediatric patients using the latest dual-source CT technology in combination with prospective ECG-triggered HPH acquisition.
心脏CT血管造影(cCTA)已成为评估先天性心脏病的既定方法。然而,必须考虑电离辐射的潜在有害影响,尤其是在年龄较小、对辐射更敏感的患者中。在本研究中,我们试图评估一家三级医疗中心8年间儿科cCTA辐射剂量的时间变化。这项回顾性研究纳入了2004年11月至2012年9月期间所有年龄≤18岁、因评估先天性心脏病或炎性疾病(川崎病)而接受心电图(ECG)门控cCTA检查的患者。在研究期间,95例患者使用3种不同的扫描仪型号进行扫描,即64层多排CT(64-MDCT)以及第一代(64-DSCT)和第二代(128-DSCT)双源CT,以及3种扫描方案,即回顾性ECG门控螺旋扫描(RG)、前瞻性ECG触发轴向扫描(PT)或前瞻性ECG触发高螺距螺旋扫描(HPH)。采用剂量长度乘积法并根据年龄调整转换因子(k)计算有效剂量(ED)。然后比较各扫描方案之间的ED。如有可用,从临床cCTA报告中提取图像质量。总体而言,94%的扫描具有诊断价值(64层MDCT为80%,64层DSCT为93%,128层DSCT为97%)。使用128-DSCT时,与64-MDCT(6.8[范围2.9 - 13.6]mSv)和64-DSCT(2.9[范围0.9 - 4.1]mSv)相比,中位ED(1.0[范围0.6 - 2.0]mSv)分别降低了85.8%和66.8%。使用HPH时,与PT(2.2[范围0.9 - 3.4]mSv)和RG(6.1[范围2.5 - 10.6]mSv)相比,中位ED(0.9[范围0.6 - 1.8]mSv)分别降低了59.4%和85.4%。现在,结合前瞻性ECG触发HPH采集技术,使用最新的双源CT技术,可以以非常低的辐射剂量为儿科患者进行cCTA检查。