Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
Chem Commun (Camb). 2013 Sep 7;49(69):7659-61. doi: 10.1039/c3cc43970d. Epub 2013 Jul 22.
Positively charged gold nanoparticles ((+)AuNPs) are electrostatically adsorbed on the negatively charged aptamers and the solution displays a blue color due to the aggregation of the (+)AuNPs, while the binding of the target lysozyme with the aptamers reduces the charge of the aptamers, which stabilizes the (+)AuNPs and the (+)AuNPs solution remains red in color.
带正电荷的金纳米粒子（(+)AuNPs）通过静电吸附在带负电荷的适体上，由于(+)AuNPs 的聚集，溶液呈现蓝色，而目标溶菌酶与适体的结合减少了适体的电荷，这稳定了(+)AuNPs，使得(+)AuNPs 溶液保持红色。
