苦荬菜属植物中两种新的齐墩果烷型三萜。
Two new chiratane-type triterpenoids from Swertia kouitchensis.
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
Molecules. 2013 Jul 18;18(7):8518-23. doi: 10.3390/molecules18078518.
Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 1-4 showed moderate inhibitory activity against the α-glucosidase (with IC₅₀ values ranging from 1,812 to 2,027 μM).
从川西獐牙菜（Swertia kouitchensis）的乙醇提取物中分离得到两种新的獐牙菜烷型三萜化合物，kouitchenoids A 和 B（1,2），以及齐墩果酸（3）和熊果酸（4）。新结构通过 MS 和 NMR 数据分析确定。此外，化合物 1-4 对α-葡萄糖苷酶表现出中等抑制活性（IC₅₀ 值范围为 1,812 至 2,027 μM）。
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