Pei X T, Wu C T
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, China.
Exp Hematol. 1990 Sep;18(8):927-31.
A natural tumor suppressor of human fetal liver origin with low molecular weight (LMW-NTS) was studied. The methanol extract of human fetal liver supernatant (FLS-MeOH), a crude preparation of LMW-NTS, showed preferential suppression on the growth of leukemic cell lines HL-60, L833, WEHI-3, and L1210, but less effect on the growth of normal bone marrow granulocyte-macrophage colony-forming units (CFU-GM) in vitro. Preliminary experiments showed that FLS-MeOH also exhibited preferential suppression on the growth of leukemic colony-forming units (L-CFU) from six patients suffering from acute myeloid leukemia (AML). In combination with a long-term in vitro liquid culture system, FLS-MeOH could be adopted as an effective purging agent in the autologous bone marrow transplantation treatment of myeloid leukemia.
对一种源自人胎肝的低分子量天然肿瘤抑制因子（LMW-NTS）进行了研究。人胎肝上清液的甲醇提取物（FLS-MeOH）是LMW-NTS的粗制品，在体外对白血病细胞系HL-60、L833、WEHI-3和L1210的生长有优先抑制作用，但对正常骨髓粒细胞-巨噬细胞集落形成单位（CFU-GM）的生长影响较小。初步实验表明，FLS-MeOH对6例急性髓系白血病（AML）患者的白血病集落形成单位（L-CFU）的生长也有优先抑制作用。结合长期体外液体培养系统，FLS-MeOH可作为髓系白血病自体骨髓移植治疗中的一种有效净化剂。
