Chichkanov G G, Tolmacheva E A, Lyskovtsev V V, Grigor'eva E K, Matsievskiĭ D D
Farmakol Toksikol. 1990 May-Jun;53(3):38-40.
The effect of a new antiarrhythmic drug bonnecor on the hemodynamics, blood supply and function of the ischemic heart as compared with the famous antiarrhythmic drugs lidocaine and ethacizine was studied in the experiments on anesthetized animals (rats, dogs) under artificial respiration. It was shown that bonnecor administered in a dose of 0.5 mg/kg was able of relieving disturbances of the cardiac hemodynamics and function produced by occlusion of the coronary artery. The drug exerted no significant effect on the blood supply to the focus of acute and chronic myocardial ischemia.
在人工呼吸条件下，在麻醉动物（大鼠、狗）实验中，研究了一种新型抗心律失常药物博内可（bonnecor）与著名抗心律失常药物利多卡因和乙卡嗪相比，对缺血心脏的血流动力学、血液供应和功能的影响。结果表明，以0.5毫克/千克的剂量给药时，博内可能够缓解冠状动脉闭塞所产生的心脏血流动力学和功能紊乱。该药物对急性和慢性心肌缺血病灶的血液供应没有显著影响。
