Tolmacheva E A, Chichkanov G G, Matsievskiĭ D D
Biull Eksp Biol Med. 1989 May;107(5):588-90.
The effect of newly-developed anti-arrhythmia drug Bonnecor compared to that of ethacizin and lidocaine has been studied on anesthetized rats under acute myocardial ischemia. The drugs injected intravenously prior to coronary artery occlusion have been shown to prevent to a great degree the appearance of hemodynamic and functional disturbances of the heart. When compared to control, less reduction in systemic arterial pressure, systolic discharge cardiac output, contractility and heart power were observed. In addition, Bonnecor has been found to have certain advantages over reference drugs.
在急性心肌缺血状态下，对麻醉大鼠研究了新开发的抗心律失常药物Bonnecor与乙吗噻嗪和利多卡因相比的效果。在冠状动脉闭塞前静脉注射这些药物已显示能在很大程度上预防心脏血液动力学和功能紊乱的出现。与对照组相比，观察到全身动脉压、心脏收缩期射血输出量、收缩性和心力的降低较少。此外，已发现Bonnecor相对于参比药物具有某些优势。
