Department of Neurological Sciences, L'Enfant-Jésus Hospital, CHU de Québec, Canada.
Neurology. 2013 Aug 20;81(8):770-1. doi: 10.1212/WNL.0b013e3182a1aa78. Epub 2013 Jul 19.
Propofol-related infusion syndrome (PRIS) is a rare but catastrophic complication of propofol use. It is clinically characterized by metabolic acidosis, rhabdomyolysis, arrhythmias, myocardial failure, renal failure, and hepatomegaly, and may lead to death. Some risk factors are associated with PRIS, namely young age, critical illness, high fat intake, catecholamine or steroid use, inborn error of fatty acid oxidation, propofol doses exceeding 4–5 mg/kg/hour, and duration of use exceeding 48 hours. Some evidence also suggests that PRIS is related to a mitochondrial toxicity of propofol.
异丙酚相关性输注综合征（PRIS）是一种罕见但具有灾难性的异丙酚使用并发症。其临床特征为代谢性酸中毒、横纹肌溶解、心律失常、心功能衰竭、肾衰竭和肝肿大，并可能导致死亡。一些与 PRIS 相关的危险因素包括：年龄较小、重病、高脂肪摄入、儿茶酚胺或类固醇使用、脂肪酸氧化的先天性错误、异丙酚剂量超过 4-5mg/kg/小时以及使用时间超过 48 小时。一些证据还表明，PRIS 与异丙酚的线粒体毒性有关。
