Cancer Research Institute, Xiangya School of Medicine, Central South University, 110 Xiang Ya Road, Changsha 410078, Hunan, China.
Expert Rev Anticancer Ther. 2013 Jul;13(7):883-93. doi: 10.1586/14737140.2013.811180.
Programmed cell death plays an important role in animal development, tissue homeostasis and eliminating harmful or virally infected cells. Necroptosis, a novel form of programmed cell death, is caspase independent but RIPK and RIPK3 dependent. Moreover, it is suggested that necroptosis can be specifically inhibited by small molecular inhibitors such as necrostatin-1. Its signaling pathways have something in common with apoptosis, although the molecular mechanisms of necroptosis need to be further elucidated. Previous evidences suggest that necroptosis has significant effects in regulating various physiological processes and disease, such as ischemic brain injury, immune system disorders and cancer. In this review, the molecular mechanism of necroptosis is described and how it could be manipulated in the treatment of cancer is summarized.
细胞程序性死亡在动物发育、组织稳态和清除有害或病毒感染细胞中发挥着重要作用。细胞程序性坏死是一种新的细胞程序性死亡形式，它不依赖于胱天蛋白酶，但依赖于 RIPK 和 RIPK3。此外，有研究表明，细胞程序性坏死可以被小分子抑制剂（如 necrostatin-1）特异性抑制。尽管细胞程序性坏死的分子机制仍需进一步阐明，但它的信号通路与细胞凋亡有一些共同之处。先前的证据表明，细胞程序性坏死在调节各种生理过程和疾病方面具有重要作用，如缺血性脑损伤、免疫系统紊乱和癌症。在这篇综述中，描述了细胞程序性坏死的分子机制，并总结了如何操纵它来治疗癌症。
