单纯疱疹病毒 1 感染角膜中的 I 型干扰素与淋巴管生成——对宿主有益吗？
Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host?
机构信息
Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
出版信息
Prog Retin Eye Res. 2013 Sep;36:281-91. doi: 10.1016/j.preteyeres.2013.06.003. Epub 2013 Jul 19.
Abstract
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that can result in significant human morbidity. Within the cornea, it was thought the initial recognition of the pathogen was through Toll-like receptors expressed on/in resident cells that then elicit pro-inflammatory cytokine production, activation of anti-viral pathways, and recruitment of leukocytes. However, our lab has uncovered a novel, TLR-independent innate sensor that supersedes TLR induction of anti-viral pathways following HSV-1 infection. In addition, we have also found HSV-1 induces the genesis of lymphatic vessels into the cornea proper by a mechanism independent of TLRs and unique in the field of neovascularization. This review will focus on these two innate immune events during acute HSV-1 infection of the cornea.
摘要
单纯疱疹病毒 1 型（HSV-1）是一种高度成功的病原体，可导致人类发病率显著增加。在角膜中，人们认为最初对病原体的识别是通过驻留在细胞上/中的 Toll 样受体（TLR）进行的，然后引发促炎细胞因子的产生、抗病毒途径的激活和白细胞的募集。然而，我们实验室发现了一种新的、非 TLR 依赖性先天传感器，它可以替代 TLR 诱导的 HSV-1 感染后的抗病毒途径。此外，我们还发现 HSV-1 通过一种独立于 TLR 的机制诱导淋巴管生成到角膜本身，这在新生血管形成领域是独特的。本综述将重点介绍这两个先天免疫事件在急性 HSV-1 感染角膜的过程中。
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