Centre for Global Heath Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada; Division of Infectious Diseases, Hospital for Sick Children, Toronto, Ontario, Canada and Department of Pediatrics, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada.
Vaccine. 2013 Sep 23;31(41):4655-61. doi: 10.1016/j.vaccine.2013.07.012. Epub 2013 Jul 19.
Direct estimates of measles mortality in India are unavailable. Our objective is, to use a nationally-representative study of mortality to estimate the number and distribution of, measles deaths in India with a focus on 264 high burden districts.
We used physician coded verbal autopsy data from the Million Death Study which surveyed, over 12,000 deaths in children aged 1 month to under 15 years from 1.1 million nationally, representative households in 2001-2003.
We estimate there were 92,000 (99% CI 63,000-137,000) measles deaths in children 1-59, months of age in India in 2005, representing a mortality rate of 3.3 (99% CI 2.3-5.0) per 1000 live, births and about 6% of all 1-59 month deaths. In children under 15 years of age, there were 107,000, (99% CI 74,000-158,000) measles deaths. The measles mortality rate was nearly 70% greater in girls, than in boys, and 60% of the deaths were in three populous states Uttar Pradesh, Bihar, and Madhya, Pradesh. The 1-59 month measles mortality rate in high burden districts was 4.48 (99% CI 3.94-5.02) compared to 2.40 (99% CI 2.28-2.52) per 1000 live births in other districts.
Measles killed over 100,000 children in India in 2005 and girls were at higher risk than boys. The majority of measles deaths occurred in a few states and high burden districts. The results of this study highlight the importance of focusing measles supplementary immunization activities in high burden districts.
印度缺乏麻疹死亡率的直接估计数据。我们的目的是利用一项全国代表性的死亡率研究，估计印度麻疹死亡人数及其分布情况，重点关注 264 个高负担地区。
我们使用了来自百万死亡研究的医生编码死因推断数据，该研究在 2001 年至 2003 年期间对来自 110 万个全国代表性家庭的 1 个月至 15 岁以下的 12000 多名儿童的死亡情况进行了调查。
我们估计，2005 年印度 1-59 月龄儿童中有 92000 例（99%置信区间 63000-137000）麻疹死亡，死亡率为每 1000 例活产 3.3 例（99%置信区间 2.3-5.0），占 1-59 月龄所有死亡的 6%左右。在 15 岁以下儿童中，有 107000 例（99%置信区间 74000-158000）麻疹死亡。女孩的麻疹死亡率比男孩高近 70%，其中 60%的死亡发生在人口最多的三个邦：北方邦、比哈尔邦和中央邦。高负担地区 1-59 月龄麻疹死亡率为每 1000 例活产 4.48 例（99%置信区间 3.94-5.02），而其他地区为每 1000 例活产 2.40 例（99%置信区间 2.28-2.52）。
2005 年，印度有超过 10 万名儿童死于麻疹，女孩的风险高于男孩。大多数麻疹死亡发生在少数几个邦和高负担地区。这项研究的结果强调了在高负担地区集中开展麻疹补充免疫活动的重要性。
