Mancia M, Imeri L, Giglio R
Institute of Human Physiology II, University of Milan, Italy.
Int J Clin Pharmacol Res. 1990;10(1-2):115-21.
The intracerebroventricular (i.c.v.) injection of acetyl-L-carnitine in the freely moving cat, during a spontaneous synchronous phase of sleep, induced the animal's arousal and a delay of the subsequent appearance of desynchronized sleep. The entity of such effects was dose dependent. The i.c.v. but not the intravenous injection of the drug proved capable of inducing a desynchronization of the characteristically synchronous electroencephalogram of an animal with a brainstem section at intercollicular midbrain level (cerveau isolé preparation), thus suggesting that the action of acetyl-L-carnitine could be exerted at a diencephalic level. Acetyl-L-carnitine could therefore modulate the sleep-wake cycle, thus facilitating the desynchronizing systems of cerebral electric activity.
在自由活动的猫处于睡眠的自发同步阶段时，向其脑室内注射乙酰-L-肉碱，会引起动物觉醒，并延迟随后去同步化睡眠的出现。这些效应的程度呈剂量依赖性。向脑室内而非静脉注射该药物，能够使在中脑间脑水平进行脑干横切的动物（孤立脑制备）特征性的同步脑电图去同步化，这表明乙酰-L-肉碱的作用可能在间脑水平发挥。因此，乙酰-L-肉碱可能调节睡眠-觉醒周期，从而促进脑电活动的去同步化系统。
