Drago F, Continella G, Pennisi G, Alloro M C, Calvani M, Scapagnini U
Pharmacol Biochem Behav. 1986 May;24(5):1393-6. doi: 10.1016/0091-3057(86)90200-5.
The behavioral activity of carnitine acetylate derivative, acetyl-l-carnitine has been studied in the male rat. Intraperitoneal (IP) injection of acetyl-l-carnitine was followed by an increase in ambulation and rearing items in the open field behavior. Both the number of conditioned avoidance response (CARs) and the percentage of learners in the acquisition of shuttle-box active avoidance behavior appeared to be increased by IP or intracerebroventricular (ICV) injection of the drug at different doses. Subchronic administration of the drug mimicked the effects found after acute injection. The number of CARs in the extinction of shuttle-box active avoidance behavior appeared to be increased after acute IP or ICV injection, and after subchronic administration of acetyl-l-carnitine. The retention of passive avoidance behavior was facilitated by IP injection of the substance. The behavioral effects of acetyl-l-carnitine may involve central mechanisms, e.g., cholinergic neurotransmission in the brain.
已在雄性大鼠中研究了肉碱乙酰化衍生物乙酰左旋肉碱的行为活性。腹腔注射乙酰左旋肉碱后，旷场行为中的行走和竖项活动增加。腹腔注射或脑室内注射不同剂量的该药物，似乎会增加条件性回避反应（CARs）的数量以及在穿梭箱主动回避行为习得过程中学习者的百分比。该药物的亚慢性给药模拟了急性注射后的效果。急性腹腔注射或脑室内注射后以及乙酰左旋肉碱亚慢性给药后，穿梭箱主动回避行为消退中的CARs数量似乎增加。腹腔注射该物质促进了被动回避行为的保持。乙酰左旋肉碱的行为效应可能涉及中枢机制，例如大脑中的胆碱能神经传递。
