Bossoni G, Carpi C
Drugs Exp Clin Res. 1986;12(11):911-6.
The aim of the study was to evaluate the effects of acetyl-L-carnitine on learning and/or memory processes in laboratory animals. In the water maze test, acetyl-L-carnitine, given intraperitoneally at doses ranging from 0.3 to 100 mg/kg, improved performances in both mice and rats. In the latter the drug also proved active when administered orally in the 3-100 mg/kg dosage range. In the pole climbing test in the rat, acetyl-L-carnitine at doses ranging from 0.03 to 10 mg/kg i.p. increased the conditioned reflex learning rate. In the passive avoidance test in the rat, significant increases in retention were observed after treatment with acetyl-L-carnitine at doses ranging from 1 to 30 mg/kg i.p. In the passive avoidance plus electroconvulsive shock test in the mouse, acetyl-L-carnitine antagonized amnesia at doses ranging from 0.1 to 3 mg/kg i.p.
该研究的目的是评估乙酰-L-肉碱对实验动物学习和/或记忆过程的影响。在水迷宫试验中，以0.3至100mg/kg的剂量腹腔注射乙酰-L-肉碱，可改善小鼠和大鼠的表现。在大鼠中，当以3至100mg/kg的剂量口服给药时，该药物也被证明具有活性。在大鼠的爬杆试验中，腹腔注射0.03至10mg/kg剂量的乙酰-L-肉碱可提高条件反射学习率。在大鼠的被动回避试验中，腹腔注射1至30mg/kg剂量的乙酰-L-肉碱后，观察到记忆保持显著增加。在小鼠的被动回避加电惊厥休克试验中，腹腔注射0.1至3mg/kg剂量的乙酰-L-肉碱可对抗失忆。
