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ROS 信号环路 - 产生、感知、调节。

ROS signaling loops - production, perception, regulation.

机构信息

Division of Plant Biology, Department of Biosciences, University of Helsinki, FI-00014 Helsinki, Finland.

出版信息

Curr Opin Plant Biol. 2013 Oct;16(5):575-82. doi: 10.1016/j.pbi.2013.07.002. Epub 2013 Jul 20.

DOI:10.1016/j.pbi.2013.07.002
PMID:23876676
Abstract

Reactive oxygen species are recognized as important signaling components in a wide range of processes in plants and most other organisms. Reactive oxygen species are produced in different subcellular compartments in response to specific stimuli and the production is under tight control in order to avoid detrimental side-effects. Calcium signaling, protein phosphorylation and other signaling pathways are intimately involved in the control and coordination of reactive oxygen production. Any signal that should result in a specific response must eventually be perceived. Direct redox modification of transcription factors and other proteins are critical for the perception of intracellular reactive oxygen species; however, sensing of their extracellular counterparts awaits elucidation.

摘要

活性氧是植物和大多数其他生物中广泛的过程中重要的信号成分。活性氧在不同的亚细胞区室中产生,以响应特定的刺激,并且生产受到严格控制,以避免有害的副作用。钙信号、蛋白质磷酸化和其他信号通路密切参与活性氧产生的控制和协调。任何应该导致特定反应的信号最终都必须被感知。转录因子和其他蛋白质的直接氧化还原修饰对于细胞内活性氧的感知至关重要;然而,其细胞外对应物的传感仍有待阐明。

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