Cao Ziyang, Liu Jing, Yang Xianzhu
Department of General Surgery Guangzhou First People's Hospital the Second Affiliated Hospital South China University of Technology Guangzhou People's Republic of China.
Center for Medical Research on Innovation and Translation Institute of Clinical Medicine School of Medicine Guangzhou First People's Hospital South China University of Technology Guangzhou People's Republic of China.
Exploration (Beijing). 2024 Mar 15;4(5):20230037. doi: 10.1002/EXP.20230037. eCollection 2024 Oct.
Recently, the field of nanomedicine has witnessed substantial advancements in the development of nanocarriers for targeted drug delivery, emerges as promising platforms to enhance therapeutic efficacy and minimize adverse effects associated with conventional chemotherapy. Notably, deformable nanocarriers have garnered considerable attention due to their unique capabilities of size changeable, tumor-specific aggregation, stimuli-triggered disintegration, and morphological transformations. These deformable nanocarriers present significant opportunities for revolutionizing drug delivery strategies, by responding to specific stimuli or environmental cues, enabling achieved various functions at the tumor site, including size-shrinkage nanocarriers enhance drug penetration, aggregative nanocarriers enhance retention effect, disintegrating nanocarriers enable controlled drug release, and shape-changing nanocarriers improve cellular uptake, allowing for personalized treatment approaches and combination therapies. This review provides an overview of recent developments and applications of deformable nanocarriers for enhancing tumor therapy, underscores the diverse design strategies employed to create deformable nanocarriers and elucidates their remarkable potential in targeted tumor therapy.
近年来，纳米医学领域在用于靶向给药的纳米载体开发方面取得了重大进展，成为增强治疗效果和最大限度减少传统化疗相关副作用的有前景的平台。值得注意的是，可变形纳米载体因其尺寸可变、肿瘤特异性聚集、刺激触发崩解和形态转变等独特能力而备受关注。这些可变形纳米载体通过响应特定刺激或环境线索，在肿瘤部位实现各种功能，包括尺寸缩小的纳米载体增强药物渗透、聚集性纳米载体增强滞留效应、崩解性纳米载体实现可控药物释放以及形状改变的纳米载体改善细胞摄取，从而为彻底改变给药策略提供了重大机遇，实现个性化治疗方法和联合疗法。本综述概述了可变形纳米载体在增强肿瘤治疗方面的最新进展和应用，强调了用于创建可变形纳米载体的多种设计策略，并阐明了它们在靶向肿瘤治疗中的巨大潜力。
