Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy.
Bone. 2013 Oct;56(2):432-9. doi: 10.1016/j.bone.2013.07.015. Epub 2013 Jul 19.
The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were used to magnetize the biomaterials with direct nucleation on collagen fibres or impregnation techniques. Minimally invasive surgery was performed on 12 rabbits to implant cylindrical NdFeB magnets in close proximity to magnetic scaffolds within the lateral condyles of the distal femoral epiphyses. Under this static magnetic field we demonstrated, for the first time in vivo, that the ability to modify the scaffold architecture could influence tissue regeneration obtaining a well-ordered tissue. Moreover, the association between NdFeB magnet and magnetic scaffolds represents a potential technique to ensure scaffold fixation avoiding micromotion at the tissue/biomaterial interface.
组织再生的基本要素是细胞、生化信号和三维微环境。在描述的方法中，矿化胶原生物材料作为支架，并为组织再生提供生化刺激。此外，还使用超顺磁纳米粒子通过在胶原纤维上直接成核或浸渍技术使生物材料磁化。对 12 只兔子进行微创外科手术，将圆柱形 NdFeB 磁体植入股骨远端骺外侧髁的磁支架附近。在这个静态磁场下，我们首次在体内证明，改变支架结构的能力可以影响组织再生，获得有序的组织。此外，NdFeB 磁铁和磁性支架之间的结合代表了一种潜在的技术，可以确保支架固定，避免组织/生物材料界面的微动。
