Chon Ilyoung, Choi Chiun, Shin Cheol Min, Park Young Su, Kim Nayoung, Lee Dong Ho
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Korean J Gastroenterol. 2013 Jun;61(6):307-12. doi: 10.4166/kjg.2013.61.6.307.
BACKGROUND/AIMS: Eradication of Helicobacter pylori reduces the incidence of gastric cancer, and may inhibit gastric dysplasia progression into gastric cancer. The aim of this study was to investigate the effect of eradication of Helicobacter on the incidence of subsequent gastric dysplasia development after endoscopic resection.
Medical records of patients who underwent endoscopic resection for gastric dysplasia were retrospectively reviewed. Presence of H. pylori was assessed by the Campylobacter-like organism test and histology. The rate of subsequent dysplasia development after endoscopic resection between the eradication group and non-eradication group was compared.
Total of 129 patients positive for H. pylori infection were included for analysis. Of these, 85 patients received successful eradication therapy and 44 patients did not receive eradication therapy or failed to achieve successful eradication. Sex, mean age and pathologic grade of dysplasia did not differ between the two groups. In univariate analysis, the grade of intestinal metaplasia (p=0.013) significantly differed between metachronous dysplasia group and non-metachrounous dysplasia group. In multivariate analysis, eradication of H. pylori (p=0.014) was related to reduced incidence of subsequent gastric dysplasia development after endoscopic resection.
Eradication of H. pylori likely has a beneficial effect in preventing the development of subsequent gastric dysplasia, a premalignant lesion of gastric cancer, after endoscopic resection.
背景/目的：根除幽门螺杆菌可降低胃癌发病率，并可能抑制胃发育异常进展为胃癌。本研究旨在探讨根除幽门螺杆菌对内镜切除术后后续胃发育异常发生率的影响。
回顾性分析因胃发育异常接受内镜切除患者的病历。通过类弯曲杆菌试验和组织学评估幽门螺杆菌的存在情况。比较根除组和未根除组内镜切除术后后续发育异常的发生率。
共纳入129例幽门螺杆菌感染阳性患者进行分析。其中，85例患者接受了成功的根除治疗，44例患者未接受根除治疗或根除失败。两组患者的性别、平均年龄和发育异常的病理分级无差异。单因素分析显示，异时性发育异常组和非异时性发育异常组之间肠化生分级（p = 0.013）有显著差异。多因素分析显示，根除幽门螺杆菌（p = 0.014）与内镜切除术后后续胃发育异常发生率降低有关。
根除幽门螺杆菌可能对预防内镜切除术后后续胃发育异常（一种胃癌前病变）的发生有有益作用。
