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内镜下切除早期胃癌后的感染。

Infection following Endoscopic Resection of Early Gastric Cancer.

机构信息

Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Biomed Res Int. 2019 Oct 16;2019:9824964. doi: 10.1155/2019/9824964. eCollection 2019.

Abstract

The role of () infection in patients following endoscopic resection of early gastric cancer (EGC) remains unclear. This article presents a review of literature published in the past 15 years. -mediated persistent methylation levels are associated with the development of metachronous gastric cancer. The methylation of certain specific genes can be used to identify patients with a high risk of metachronous gastric cancer even after eradication. eradication after endoscopic resection should be performed as early as possible for eradication success and prevention of metachronous precancerous lesions. Although whether the eradication of could prevent the development of metachronous cancer after endoscopic resection is controversial, several meta-analyses concluded that eradication could reduce the incidence of metachronous gastric cancer significantly. In addition, eradication in gastric cancer survivors after endoscopic resection could reduce healthcare cost and save lives in a cost-effective way. Taken together, eradication after endoscopic resection of EGC is recommended as prevention for metachronous precancerous lesions and metachronous gastric cancer.

摘要

()感染在接受内镜下早期胃癌(EGC)切除的患者中的作用仍不清楚。本文回顾了过去 15 年发表的文献。-介导的持续甲基化水平与胃癌的发生有关。特定基因的甲基化可用于识别即使在根除后仍具有高胃癌发生风险的患者。根除应尽早进行,以实现根除成功和预防异时性癌前病变。虽然内镜切除后是否能根除可预防异时性癌症的发展仍存在争议,但几项荟萃分析得出结论,根除可显著降低异时性胃癌的发生率。此外,内镜切除后胃癌幸存者的根除可节省医疗成本并以具有成本效益的方式挽救生命。综上所述,建议对 EGC 内镜切除后进行根除以预防异时性癌前病变和异时性胃癌。

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