铁催化二炔和氰酰胺生成 2-氨基吡啶。
Iron-catalyzed formation of 2-aminopyridines from diynes and cyanamides.
机构信息
Department of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, Utah 84112-0850, USA.
出版信息
J Org Chem. 2012 Sep 7;77(17):7555-63. doi: 10.1021/jo3012418. Epub 2012 Aug 14.
Abstract
Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.
摘要
二炔和氰酰胺在铁催化下发生[2 + 2 + 2]环加成反应，以高产率和区域选择性的方式形成高度取代的 2-氨基吡啶。该体系还用于环化两个末端炔烃和一个氰酰胺，以区域选择性地得到 2,4,6-三取代吡啶产物。
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