Zeigler V L, Gillette P C, Crawford F A, Wiles H B, Fyfe D A
Division of Cardiovascular Nursing, Medical University of South Carolina, Charleston 29425.
J Am Coll Cardiol. 1990 Sep;16(3):681-5. doi: 10.1016/0735-1097(90)90360-2.
It was assumed that the availability of new antiarrhythmic drugs and new surgical techniques might allow medical or nonexcisional surgical treatment in many young children with incessant ventricular tachycardia. Fourteen infants and young children less than 5 years of age were evaluated and treated for incessant ventricular tachycardia. Medical treatment was pursued up to the use of amiodarone with a type Ib or Ic antiarrhythmic drug unless the patient became hemodynamically unstable. Patients underwent surgery when these drug regimens failed or when moderate congestive heart failure was present. Seven patients were successfully treated medically and seven underwent surgical treatment. Of those treated surgically, five had cryothermic lesions and two had excisions. Five of the surgically treated patients required temporary additional medical treatment. Follow-up ranged from 12 to 53 months (mean 28). Eleven of the 14 patients are currently not taking any antiarrhythmic medication. No patient required a pacemaker, none received anticongestive medications and none died.
人们认为,新型抗心律失常药物和新的外科技术的出现,可能使许多患有持续性室性心动过速的幼儿能够接受药物治疗或非切除性手术治疗。对14名5岁以下的婴幼儿进行了持续性室性心动过速的评估和治疗。除非患者出现血流动力学不稳定,否则会一直采用药物治疗,直至使用胺碘酮联合Ib类或Ic类抗心律失常药物。当这些药物治疗方案失败或出现中度充血性心力衰竭时,患者接受手术治疗。7例患者药物治疗成功,7例接受手术治疗。在接受手术治疗的患者中,5例进行了冷冻消融,2例进行了切除手术。5例接受手术治疗的患者需要临时追加药物治疗。随访时间为12至53个月(平均28个月)。14例患者中有11例目前未服用任何抗心律失常药物。没有患者需要起搏器,无人接受抗充血药物治疗,也无人死亡。