Mak J W, Lam P L, Choong M F, Suresh K
Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
J Helminthol. 1990 Jun;64(2):96-9. doi: 10.1017/s0022149x00011986.
The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata. As expected, intravenous suramin at 10 mg/kg daily x 5 days or 17 mg/kg weekly x 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50.6% and 13.6% of controls respectively. Oral diethylcarbamazine citrate at 6 mg/kg daily x 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4.5% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.
已知的杀丝虫药苏拉明和枸橼酸乙胺嗪，针对叶猴（白臀叶猴）体内的亚周期型马来布鲁线虫感染进行了测试。正如预期的那样，每日静脉注射10mg/kg苏拉明，共5天，或每周静脉注射17mg/kg，共5周，均未显示出任何杀微丝蚴活性，但分别将存活成虫的回收率大幅降低至对照组的50.6%和13.6%。每日口服6mg/kg枸橼酸乙胺嗪，共6天或10天，治疗四周后最终微丝蚴计数降至初始计数的30%，成虫回收率分别降至对照组的4.5%和0%。尽管这些药物在这种非人灵长类动物模型中针对该感染的抗丝虫活性似乎与在人类中观察到的相似，但这些结果必须使用更大数量的动物群体来加以证实。
