Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA.
Mar Drugs. 2013 Jul 16;11(7):2510-73. doi: 10.3390/md11072510.
The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998-2008 reviews of this series. The pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner. Antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral pharmacological activities were reported for 102 marine natural products. Additionally, 60 marine compounds were observed to affect the immune and nervous system as well as possess antidiabetic and anti-inflammatory effects. Finally, 68 marine metabolites were shown to interact with a variety of receptors and molecular targets, and thus will probably contribute to multiple pharmacological classes upon further mechanism of action studies. Marine pharmacology during 2009-2011 remained a global enterprise, with researchers from 35 countries, and the United States, contributing to the preclinical pharmacology of 262 marine compounds which are part of the preclinical pharmaceutical pipeline. Continued pharmacological research with marine natural products will contribute to enhance the marine pharmaceutical clinical pipeline, which in 2013 consisted of 17 marine natural products, analogs or derivatives targeting a limited number of disease categories.
本文呈现了 2009 年至 2011 年经过同行评审的海洋药理学文献，采用了本系列 1998 年至 2008 年评论中使用的格式。本文全面讨论了从海洋动物、藻类、真菌和细菌中分离出的结构特征化合物的药理学。报告了 102 种海洋天然产物具有抗菌、抗真菌、抗原生动物、抗结核和抗病毒的药理活性。此外，观察到 60 种海洋化合物影响免疫系统和神经系统，并具有抗糖尿病和抗炎作用。最后，有 68 种海洋代谢物与多种受体和分子靶标相互作用，因此在进一步的作用机制研究后，可能会对多种药理学类别做出贡献。2009-2011 年期间，海洋药理学仍然是一项全球性的事业，来自 35 个国家的研究人员，以及美国，为 262 种海洋化合物的临床前药理学做出了贡献，这些化合物是临床前药物管道的一部分。继续对海洋天然产物进行药理学研究将有助于增强海洋药物临床管道，到 2013 年，该管道包含 17 种海洋天然产物、类似物或衍生物，针对有限数量的疾病类别。
