Menezes Vinícius Paulino Pinto, Silva Filho Aldeni Moreira da, Costa Aline Jeferson, Nascimento Elielton, Pinheiro Ulisses Santos, Chaves Renata Pinheiro, Andrade Alexandre Lopes, Vasconcelos Mayron Alves de, Teixeira Edson Holanda, Sampaio Alexandre Holanda, Nagano Celso Shiniti, Carneiro Rômulo Farias
Laboratório de Biotecnologia Marinha-BioMar, Departamento de Engenharia de Pesca, Universidade Federal do Ceará, Av. Humberto Monte, s/n, Campus do Pici, bloco 871, Fortaleza 60440-970, CE, Brazil.
Departamento de Zoologia, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife 50670-901, PE, Brazil.
Microorganisms. 2025 Apr 18;13(4):940. doi: 10.3390/microorganisms13040940.
This study evaluated the antibacterial activity of aqueous and organic extracts from 78 marine organisms, including seaweeds and sponges, collected along the coast of Ceará, Brazil. Extracts were obtained by maceration using distilled water and 50% acetonitrile and tested against , (Gram-positive), and (Gram-negative) using the disk diffusion method, and inhibition zone diameters were measured. Antibacterial activity was observed in 30.7% of the extracts, with organic extracts showing higher efficacy. Several sponge species, particularly those from the genus , as well as , , sp., and sp., demonstrated notable inhibitory effects. While seaweed aqueous extracts showed no activity, some organic extracts-especially from -were effective against Gram-positive strains. In general, Gram-positive bacteria were more susceptible than Gram-negative bacteria. These findings underscore the biotechnological potential of marine organisms from the Brazilian coast as promising sources of antibacterial compounds and support future efforts focused on the isolation, characterization, and toxicological evaluation of active metabolites for pharmaceutical and industrial applications.
本研究评估了从巴西塞阿拉海岸采集的78种海洋生物（包括海藻和海绵）的水提取物和有机提取物的抗菌活性。提取物通过用蒸馏水和50%乙腈浸渍获得，并使用纸片扩散法针对金黄色葡萄球菌（革兰氏阳性菌）和大肠杆菌（革兰氏阴性菌）进行测试，同时测量抑菌圈直径。在30.7%的提取物中观察到了抗菌活性，其中有机提取物显示出更高的功效。几种海绵物种，特别是来自Xestospongia属的物种，以及Ircinia variabilis、Ircinia felix、Stylissa carteri和Spheciospongia vesparium，表现出显著的抑制作用。虽然海藻水提取物没有活性，但一些有机提取物——尤其是来自Padina gymnospora的提取物——对革兰氏阳性菌株有效。总体而言，革兰氏阳性菌比革兰氏阴性菌更易受影响。这些发现强调了巴西海岸海洋生物作为有前景的抗菌化合物来源的生物技术潜力，并支持未来致力于活性代谢物的分离、表征以及用于制药和工业应用的毒理学评估的工作。
