Rothwell N J, Stock M J
Comp Biochem Physiol A Comp Physiol. 1985;81(1):99-102. doi: 10.1016/0300-9629(85)90273-7.
A single injection of ACTH stimulated metabolic rate in the rat, and this effect was enhanced in hyperphagic cafeteria-fed rats. Chronic treatment with ACTH significantly reduced body weight, energy gain and energetic efficiency in stock-fed rats. Thermogenic responses to noradrenaline and a single meal, and purine nucleotide (GDP) binding to brown adipose tissue (BAT) mitochondria were also increased. Cafeteria feeding induced hyperphagia, increases in metabolic rate, acute thermogenic responses and BAT activity, and depressed energetic efficiency. ACTH had no additional effects on energy balance, thermogenic responses or brown fat in cafeteria-fed rats. These data indicate that stimulation of thermogenesis and BAT activity by ACTH resembles that induced by hyperphagia, and this effect may be partly responsible for the changes in energy balance after adrenalectomy seen in previous studies. However, acute and chronic responses to ACTH depend upon the nutritional status of the animal.
单次注射促肾上腺皮质激素（ACTH）可刺激大鼠的代谢率，这种效应在食欲亢进的自由进食大鼠中增强。对标准饲养的大鼠长期使用ACTH治疗可显著降低体重、能量增加和能量效率。对去甲肾上腺素和单餐的产热反应以及嘌呤核苷酸（GDP）与棕色脂肪组织（BAT）线粒体的结合也增加。自由进食导致食欲亢进、代谢率增加、急性产热反应和BAT活性增加，以及能量效率降低。ACTH对自由进食大鼠的能量平衡、产热反应或棕色脂肪没有额外影响。这些数据表明，ACTH对产热和BAT活性的刺激类似于食欲亢进所诱导的刺激，这种效应可能部分解释了先前研究中肾上腺切除术后能量平衡的变化。然而，对ACTH的急性和慢性反应取决于动物的营养状况。
