Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain.
Int J Eat Disord. 2013 Dec;46(8):855-61. doi: 10.1002/eat.22166. Epub 2013 Jul 23.
Starvation-induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal-weight controls and their relation with the disease duration and weight restoration.
We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal-weight controls who were eating healthily. We determined by enzyme-linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin-2 (LCN2), leptin, tumor necrosis factor receptor-II (TNFRII), interleukin-6 (IL6), adipocyte fatty acid binding protein-4 (FABP4), ghrelin, and resistin.
The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = -0.372, p = 0.033; r = -0.450, p = 0.038, respectively). Furthermore, the lipid binding-proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = -0.456, p = 0.039; r = -0.536, p = 0.015, respectively).
These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration.
众所周知，神经性厌食症（AN）中脂肪储存的饥饿性消耗伴随着一些循环脂肪细胞因子的改变。我们分析了 AN 女性与正常体重对照组之间一系列循环脂肪细胞因子，并分析了它们与疾病持续时间和体重恢复的关系。
我们分析了 28 名 AN 患者和 33 名健康饮食的正常体重对照组的循环脂肪细胞因子水平。我们通过酶联免疫吸附试验测定了总分子量和高分子量（HMW）脂联素、脂联素-2（LCN2）、瘦素、肿瘤坏死因子受体-II（TNFRII）、白细胞介素-6（IL6）、脂肪细胞脂肪酸结合蛋白-4（FABP4）、胃饥饿素和抵抗素的循环水平。
与对照组相比，AN 女性的两种循环形式的脂联素水平较高。总分子量和 HMW 脂联素与疾病持续时间呈负相关（r = -0.372，p = 0.033；r = -0.450，p = 0.038）。此外，与对照组相比，AN 患者的脂质结合蛋白 LCN2 和 FABP4 水平较低。最后，与对照组相比，AN 患者的瘦素水平较低，与疾病持续时间呈正相关（r = 0.537，p = 0.007）。抵抗素、胃饥饿素、TNFRII 和白细胞介素-6 在两组中的值相似，尽管 TNFRII 和胃饥饿素与治疗结束时体重指数的变化呈负相关（r = -0.456，p = 0.039；r = -0.536，p = 0.015）。
这些结果表明，有必要研究脂肪细胞因子水平的变化是否可以作为体重恢复的生物标志物。需要进一步的研究来阐明这些分子在体重恢复时间中的具体作用。
