Lin Qionghua, Shen Jie, Shen Lihua, Zhang Zhongwei, Fu Fengming
Crit Care. 2013 Jul 24;17(4):R155. doi: 10.1186/cc12834.
Heparin-binding protein (HBP) is an antimicrobial protein stored in neutrophil granules and plays a role in endothelial permeability regulation. The aim was to assess the diagnostic and prognostic value of measuring HBP in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
Plasma HBP was collected from 78 patients with ALI/ARDS, 28 patients with cardiogenic pulmonary edema (CPE) and 20 healthy volunteers at enrollment. Levels of HBP were measured by ELISA.
Patients with ALI/ARDS had significantly higher median levels of HBP compared with patients with CPE (17.15 (11.95 to 24.07) ng/ml vs. 9.50 (7.98 to 12.18) ng/ml, P <0.001) at enrollment. There was no significant difference between CPE patients and healthy subjects in terms of HBP value (P = 0.372). The HBP levels of nonsurvivors was significantly higher than that of survivors (23.90 (14.81 to 32.45) ng/ml vs. 16.01 (10.97 to 21.06) ng/ml, P = 0.012) and multivariate logistic regression showed HBP (odds ratio =1.52, P = 0.034) was the independent predictor for 30-day mortality in patients with ALI/ARDS.
Plasma HBP levels of ALI/ARDS patients were significantly higher than that of CPE patients. HBP was a strong prognostic marker for short-term mortality in ALI/ARDS.
肝素结合蛋白（HBP）是一种储存在中性粒细胞颗粒中的抗菌蛋白，在内皮通透性调节中发挥作用。目的是评估检测急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）患者的HBP的诊断和预后价值。
在入组时，收集了78例ALI/ARDS患者、28例心源性肺水肿（CPE）患者和20名健康志愿者的血浆HBP。通过酶联免疫吸附测定法（ELISA）检测HBP水平。
在入组时，ALI/ARDS患者的HBP中位数水平显著高于CPE患者（17.15（11.95至24.07）纳克/毫升 vs. 9.50（7.98至12.18）纳克/毫升，P<0.001）。CPE患者和健康受试者之间的HBP值无显著差异（P = 0.372）。非幸存者的HBP水平显著高于幸存者（23.90（14.81至32.45）纳克/毫升 vs. 16.01（10.97至21.06）纳克/毫升，P = 0.012），多因素逻辑回归显示HBP（比值比=1.52，P = 0.034）是ALI/ARDS患者30天死亡率的独立预测因子。
ALI/ARDS患者的血浆HBP水平显著高于CPE患者。HBP是ALI/ARDS短期死亡率的强有力的预后标志物。
Zotero 插件
