亚麻籽中的木脂素含量会影响其在健康男性和女性中的生物效应。

Lignan content of the flaxseed influences its biological effects in healthy men and women.

机构信息

Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of California at Davis, Davis, California, USA.

出版信息

J Am Coll Nutr. 2013;32(3):194-9. doi: 10.1080/07315724.2013.791147.

DOI:10.1080/07315724.2013.791147

PMID:23885993

Abstract

OBJECTIVE

The omega-3 polyunsaturated fatty acid (n-3 PUFA) as well as lignan components of flaxseed (FLX) can have beneficial effects. In this 6-week-long, randomized, double-blinded, placebo-controlled study, we investigated the effects of FLX lignans on cardiovascular risk factors.

METHODS

Thirty-seven subjects (13 men and 24 women, age: 54±7 years, body mass index [BMI]: 29.7±1 kg/m2) consumed nutrition bars with similar macronutrient contents. The fatty acid composition and the lignan contents of the bars differed significantly. Two FLX bars both contained 3.0 g of alpha linolenic acid (ALA: 18:3 n-3) but different amount of lignans (0.15 g vs. 0.41 g).

RESULTS

High-lignan FLX decreased total cholesterol (C) by 12% (p=0.044), LDL-C by 15% (p=0.022), and oxidized (Ox)-LDL by 25% (p=0.035). Regular FLX tended to increase Ox-LDL by 13% (p=0.051). The difference between the effects of high-lignan vs. regular lignan FLX on Ox-LDL was highly significant (p=0.004).

CONCLUSION

High-lignan FLX has the unique property of decreasing Ox-LDL, which is an independent risk factor for cardiovascular disease.

摘要

目的

ω-3 多不饱和脂肪酸（n-3PUFA）以及亚麻籽（FLX）中的木脂素成分可能具有有益的作用。在这项为期 6 周的随机、双盲、安慰剂对照研究中，我们研究了 FLX 木脂素对心血管危险因素的影响。

方法

37 名受试者（13 名男性和 24 名女性，年龄：54±7 岁，体重指数 [BMI]：29.7±1kg/m2）食用了具有相似宏量营养素含量的营养棒。棒的脂肪酸组成和木脂素含量有很大的差异。两种 FLX 棒均含有 3.0 克α-亚麻酸（ALA：18:3n-3），但木脂素的含量不同（0.15 克比 0.41 克）。

结果

高木脂素 FLX 使总胆固醇（C）降低了 12%（p=0.044），LDL-C 降低了 15%（p=0.022），氧化型 LDL（Ox-LDL）降低了 25%（p=0.035）。常规 FLX 使 Ox-LDL 增加了 13%（p=0.051）。高木脂素与常规木脂素 FLX 对 Ox-LDL 的作用之间的差异具有高度显著性（p=0.004）。