Jawhara Samir
Centre National de la Recherche Scientifique, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France.
Institut National de la Santé et de la Recherche Médicale U1285, University of Lille, F-59000 Lille, France.
Microorganisms. 2024 Jul 31;12(8):1570. doi: 10.3390/microorganisms12081570.
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, involves chronic inflammatory disorders of the digestive tract. Oxidative stress, associated with increased reactive oxygen species generation, is a major risk factor for IBD pathogenesis. Industrialized lifestyles expose us to a variety of factors that contribute to deteriorating gut health, especially for IBD patients. Many alternative therapeutic strategies have been developed against oxidative stress along with conventional therapy to alleviate IBD pathogenesis. Polyphenol-rich foods have attracted growing interest from scientists due to their antioxidant properties. Polyphenols are natural compounds found in plants, fruits, vegetables, and nuts that exhibit antioxidant properties and protect the body from oxidative damage. This review presents an overview of polyphenol benefits and describes the different types of polyphenols. It also discusses polyphenols' role in inhibiting oxidative stress and fungal growth prevention. Overall, this review highlights how a healthy and balanced diet and avoiding the industrialized lifestyles of our modern society can minimize oxidative stress damage and protect against pathogen infections. It also highlights how polyphenol-rich foods play an important role in protecting against oxidative stress and fungal growth.
炎症性肠病（IBD），包括克罗恩病和溃疡性结肠炎，是涉及消化道的慢性炎症性疾病。氧化应激与活性氧生成增加相关，是IBD发病机制的主要危险因素。工业化的生活方式使我们暴露于多种导致肠道健康恶化的因素中，尤其是对IBD患者而言。除了传统疗法外，人们还开发了许多针对氧化应激的替代治疗策略，以减轻IBD的发病机制。富含多酚的食物因其抗氧化特性而越来越受到科学家的关注。多酚是在植物、水果、蔬菜和坚果中发现的天然化合物，具有抗氧化特性，可保护身体免受氧化损伤。本综述概述了多酚的益处，并描述了不同类型的多酚。它还讨论了多酚在抑制氧化应激和预防真菌生长中的作用。总体而言，本综述强调了健康均衡的饮食以及避免现代社会的工业化生活方式如何能够将氧化应激损伤降至最低，并预防病原体感染。它还强调了富含多酚的食物在预防氧化应激和真菌生长方面如何发挥重要作用。
