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酪氨酸激酶FER的睾丸特异性转录本(ferT)在精子发生过程中以阶段特异性方式表达。

The testis-specific transcript (ferT) of the tyrosine kinase FER is expressed during spermatogenesis in a stage-specific manner.

作者信息

Keshet E, Itin A, Fischman K, Nir U

机构信息

Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

出版信息

Mol Cell Biol. 1990 Sep;10(9):5021-5. doi: 10.1128/mcb.10.9.5021-5025.1990.

Abstract

ferT is a testis-specific transcript of FER encoding a truncated version of the potential tyrosine kinase. Using in situ hybridization analysis, we found that ferT was transiently expressed during spermatogenesis and that expression was restricted to spermatocytes at the pachytene stage of meiotic prophase. This pattern of expression is unprecedented by other tyrosine kinases and suggests a role for ferT in a particular stage of spermatogenesis.

摘要

ferT是FER的睾丸特异性转录本,编码一种潜在酪氨酸激酶的截短版本。通过原位杂交分析,我们发现ferT在精子发生过程中短暂表达,且表达仅限于减数分裂前期粗线期的精母细胞。这种表达模式在其他酪氨酸激酶中是前所未有的,表明ferT在精子发生的特定阶段发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fab/361143/aaec465df381/molcellb00045-0594-a.jpg

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