Policlinic for Dermatology and Venerology, Saint Kliment Ohridski University, University Hospital Lozenetz, Sofia, Bulgaria.
Dermatol Ther (Heidelb). 2013 May 25;3(1):33-40. doi: 10.1007/s13555-013-0027-9. Print 2013 Jun.
The intention of this review on nevus comedonicus (NC) is to update on clinical features, pathogenesis, and therapy. NC is a rare epidermal nevus type. It is part of the nevus comedonicus syndrome, a neurocutaneous disorder with ocular, skeletal, and central nervous symptoms. Recently, acne-related signaling pathways and somatic mutations of tyrosine kinase receptors have been identified and may play a role in NC pathogenesis. On preexistent NC secondary skin tumors can develop, which are often benign. Treatment options of NC include topical therapy, laser, and surgery.
这篇关于化脓性汗腺棘皮瘤（NC）的综述旨在更新其临床特征、发病机制和治疗方法。NC 是一种罕见的表皮痣类型。它是化脓性汗腺棘皮瘤综合征的一部分，这是一种神经皮肤疾病，伴有眼部、骨骼和中枢神经系统症状。最近，已确定与痤疮相关的信号通路和酪氨酸激酶受体的体细胞突变可能在 NC 的发病机制中起作用。在先前存在的 NC 上可以继发皮肤肿瘤，这些肿瘤通常是良性的。NC 的治疗选择包括局部治疗、激光和手术。
