Kennedy S H, Brown G M, Garfinkel P E, McVey G, Parienti V
Department of Psychiatry, University of Toronto, Ont., Canada.
Psychiatry Res. 1990 Jun;32(3):221-7. doi: 10.1016/0165-1781(90)90027-3.
Urinary excretion of the principal melatonin metabolite, sulphatoxy melatonin (aMT6s), was assessed both during the day and during the night in 38 female eating disorder patients (anorexia nervosa, n = 17; bulimia nervosa, n = 12; anorexia nervosa + bulimia nervosa, n = 9) and 14 female control subjects. Correlations between nocturnal serum melatonin and urinary aMT6s were also obtained. All patient groups and the controls showed a preservation of diurnal rhythm with elevated nocturnal urinary aMT6s values and no significant difference in amplitude between groups. However, patients with concurrent major depression had significantly lower levels of daytime and nighttime urinary aMT6s than the nondepressed group. Weight did not influence these findings. Correlations between nocturnal serum melatonin levels and urinary aMT6s were high for control subjects (r = 0.77) and moderate for the patient groups (r = 0.31). This may reflect differences in the rate of excretion of melatonin between patients and controls.
在38名女性饮食失调患者（神经性厌食症，n = 17；神经性贪食症，n = 12；神经性厌食症 + 神经性贪食症，n = 9）和14名女性对照受试者中，对褪黑素主要代谢产物硫酸氧基褪黑素（aMT6s）的日间和夜间尿排泄情况进行了评估。还获得了夜间血清褪黑素与尿aMT6s之间的相关性。所有患者组和对照组均表现出昼夜节律保留，夜间尿aMT6s值升高，且组间幅度无显著差异。然而，伴有重度抑郁症的患者白天和夜间尿aMT6s水平显著低于无抑郁症组。体重并未影响这些结果。对照受试者夜间血清褪黑素水平与尿aMT6s之间的相关性较高（r = 0.77），而患者组的相关性中等（r = 0.31）。这可能反映了患者与对照之间褪黑素排泄率的差异。
