First Department of Medicine, University of Szeged, Szeged, Hungary.
Pancreatology. 2013 Jul-Aug;13(4):333-5. doi: 10.1016/j.pan.2013.05.011. Epub 2013 Jun 10.
Acute pancreatitis recently became the most common cause for hospitalization among gastrointestinal diseases. There is no specific therapy against the disease due to insufficient understanding of pathogenesis. Animal and in vitro models indicated that reduced pancreatic ductal bicarbonate secretion and consequent intraductal acidosis is an early event in acute pancreatitis, but human data are lacking. Therefore, our aim was to determine the luminal pH in the main pancreatic duct during acute pancreatitis in humans. Intraductal pH was measured in patients with acute biliary pancreatitis (n = 6) during endoscopic retrograde cholangio-pancreatography. Patients with common bile stones without pancreatitis (n = 5) and a patient with an adenoma of the papilla of Vater served as controls. The luminal pH was significantly lower in the group of acute biliary pancreatitis vs. controls (6.97 ± 0.13 vs. 7.79 ± 0.20). Our brief report shows for the first time that there is marked intraductal acidosis in acute biliary pancreatitis, which seems to worsen with time. Further clinical trials are needed to determine the exact roles of reduced intraductal pH in ABP.
急性胰腺炎最近成为胃肠道疾病中最常见的住院原因。由于对发病机制的了解不足，目前还没有针对这种疾病的特定疗法。动物和体外模型表明，减少胰腺导管碳酸氢盐分泌和随之而来的导管内酸中毒是急性胰腺炎的早期事件，但人类数据缺乏。因此，我们的目的是确定人类急性胰腺炎期间主胰管内的管腔 pH 值。在经内镜逆行胰胆管造影术期间，我们测量了急性胆源性胰腺炎患者（n = 6）的胰管内 pH 值。患有胆总管结石但无胰腺炎的患者（n = 5）和乳头壶腹腺瘤患者作为对照。与对照组相比，急性胆源性胰腺炎组的管腔 pH 值明显较低（6.97 ± 0.13 对 7.79 ± 0.20）。我们的简短报告首次表明，急性胆源性胰腺炎存在明显的导管内酸中毒，且似乎随时间恶化。需要进一步的临床试验来确定降低的胰管内 pH 值在 ABP 中的确切作用。
