Shim Jiwon
BMB Rep. 2015 Apr;48(4):223-8. doi: 10.5483/bmbrep.2015.48.4.273.
The Drosophila lymph gland is the hematopoietic organ in which stem-like progenitors proliferate and give rise to myeloid-type blood cells. Mechanisms involved in Drosophila hematopoiesis are well established and known to be conserved in the vertebrate system. Recent studies in Drosophila lymph gland have provided novel insights into how external and internal stresses integrate into blood progenitor maintenance mechanisms and the control of blood cell fate decision. In this review, I will introduce a developmental overview of the Drosophila hematopoietic system, and recent understandings of how the system uses developmental signals not only for hematopoiesis but also as sensors for stress and environmental changes to elicit necessary blood responses.
果蝇淋巴腺是造血器官，其中类干细胞祖细胞增殖并产生髓样血细胞。果蝇造血过程中涉及的机制已得到充分确立，并且已知在脊椎动物系统中是保守的。最近对果蝇淋巴腺的研究为外部和内部压力如何整合到血液祖细胞维持机制以及血细胞命运决定的控制方面提供了新的见解。在这篇综述中，我将介绍果蝇造血系统的发育概况，以及对该系统如何不仅利用发育信号进行造血，还将其用作应激和环境变化的传感器以引发必要血液反应的最新认识。
