Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea.
Virology. 2013 Sep;444(1-2):394-403. doi: 10.1016/j.virol.2013.07.006. Epub 2013 Jul 23.
The in vivo role of alveolar macrophages in the infections with 2009 pandemic H1N1 influenza virus is not as yet known. Ferret study shows that alveolar macrophages are critical for lowering the risk of severe outcomes in 2009 pandemic H1N1 influenza virus infections. Up to 40% of the infected ferrets depleted of alveolar macrophages died, with elevated body temperature and major loss of body weight in contrast to infected ferrets not depleted of alveolar macrophages. The higher viral titers in the lungs were detected in infected ferrets depleted of alveolar macrophages than infected ferrets not depleted of alveolar macrophages 5 days after infection. The inflammatory chemokines were induced at greater levels in the lungs of infected ferrets depleted of alveolar macrophages than in those of infected ferrets not depleted of alveolar macrophages. Our study implies that alveolar macrophages are important for controlling the infections of 2009 pandemic H1N1 influenza virus.
肺泡巨噬细胞在感染 2009 年大流行 H1N1 流感病毒中的体内作用尚不清楚。雪貂研究表明，肺泡巨噬细胞对于降低感染 2009 年大流行 H1N1 流感病毒后出现严重后果的风险至关重要。多达 40%的肺泡巨噬细胞耗竭的感染雪貂死亡，体温升高，体重明显减轻，而未耗竭肺泡巨噬细胞的感染雪貂则没有出现这种情况。与未耗竭肺泡巨噬细胞的感染雪貂相比，感染后 5 天，肺泡巨噬细胞耗竭的感染雪貂肺部的病毒滴度更高。感染后，肺泡巨噬细胞耗竭的雪貂肺部的炎症趋化因子的诱导水平高于未耗竭肺泡巨噬细胞的雪貂。我们的研究表明，肺泡巨噬细胞对于控制 2009 年大流行 H1N1 流感病毒的感染很重要。
