可溶性胸腺因子诱导法氏囊中T细胞分化
Induction of T-cell differentiation in the Bursa of Fabricius by a soluble thymus factor.
作者信息
Teodorczk J A, Potworowski E F
出版信息
Immunology. 1975 Apr;28(4):711-7.
Bursal lymphocytes from White Leghorn chickens of different ages were incubated with a soluble thymus factor (STF), and tested for t-cell characteristics. Immunofluorescence staining with anti-T-cell serum showed a marked increase inthe percentage of bursal T lymphocytes in cell preparations from young chickensincubated with STF. In older chickens (17 weeks) no such effect was observed. Bursal cells treated with STF were also able to elicit splenomegaly showing thatnot only antigenic but also functional T-cell characteristics had been induced in apopulation of bursal cells. The fate of these bursal T-cell precursors is discussed in the context of known migratory patterns.
将来自不同年龄白来航鸡的法氏囊淋巴细胞与可溶性胸腺因子（STF）一起孵育，并检测其T细胞特性。用抗T细胞血清进行免疫荧光染色显示，在与STF孵育的幼鸡细胞制剂中，法氏囊T淋巴细胞的百分比显著增加。在 older chickens（17周龄）中未观察到这种效应。用STF处理的法氏囊细胞也能够引起脾肿大，这表明在一群法氏囊细胞中不仅诱导了抗原性而且诱导了功能性T细胞特性。在已知迁移模式的背景下讨论了这些法氏囊T细胞前体的命运。 （注：原文中“older chickens”直接保留英文未翻译完整，推测可能是表述有误，正常应翻译为“大龄鸡”之类准确表述）
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