Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, 2720 Herlev, Denmark; Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Building 8, Bispebjerg Bakke 23, 2400 Copenhagen NW, Denmark.
Best Pract Res Clin Obstet Gynaecol. 2013 Oct;27(5):673-88. doi: 10.1016/j.bpobgyn.2013.06.001. Epub 2013 Jul 26.
Loss of musculoskeletal mass and function is a natural ageing trait, reinforced by an unhealthy life style. Loss of bone (osteoporosis) and muscle (sarcopaenia) are conditions whose prevalence are increasing because of the change in population distribution in the western world towards an older mean age. Improvements in lifestyle factors, such as diet, smoking and exercise, are the most powerful tools to combat this decline efficiently; however, public health interventions aimed at tackling these problems have shown abysmal success at the population level, mostly due to failure in compliance. With these issues in mind, we believe that the primary prevention modality in coming decades will be pharmacological. We review the basic biology of musculoskeletal ageing and what measures can be taken to prevent ageing-associated loss of musculoskeletal mass and function, with particular emphasis on pharmacological means.
肌肉骨骼质量和功能的丧失是一种自然的衰老特征，不健康的生活方式会加剧这种特征。由于西方世界人口分布向平均年龄更大的方向转变，骨质疏松症和肌肉减少症的发病率正在上升。改善生活方式因素，如饮食、吸烟和锻炼，是有效对抗这种衰退的最有力工具；然而，旨在解决这些问题的公共卫生干预措施在人群层面上收效甚微，主要是因为未能遵守。考虑到这些问题，我们认为未来几十年的主要预防方式将是药理学方法。我们回顾了肌肉骨骼衰老的基本生物学，以及可以采取哪些措施来预防与衰老相关的肌肉骨骼质量和功能丧失，特别强调了药理学手段。
