School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
School of Automation Engineering, University of Electronic Science and Technology, Chengdu, China.
Front Immunol. 2024 May 7;15:1405621. doi: 10.3389/fimmu.2024.1405621. eCollection 2024.
Ageing is an inevitable process that affects various tissues and organs of the human body, leading to a series of physiological and pathological changes. Mechanisms such as telomere depletion, stem cell depletion, macrophage dysfunction, and cellular senescence gradually manifest in the body, significantly increasing the incidence of diseases in elderly individuals. These mechanisms interact with each other, profoundly impacting the quality of life of older adults. As the ageing population continues to grow, the burden on the public health system is expected to intensify. Globally, the prevalence of musculoskeletal system diseases in elderly individuals is increasing, resulting in reduced limb mobility and prolonged suffering. This review aims to elucidate the mechanisms of ageing and their interplay while exploring their impact on diseases such as osteoarthritis, osteoporosis, and sarcopenia. By delving into the mechanisms of ageing, further research can be conducted to prevent and mitigate its effects, with the ultimate goal of alleviating the suffering of elderly patients in the future.
衰老是一个不可避免的过程，影响着人体的各种组织和器官，导致一系列生理和病理变化。端粒耗竭、干细胞耗竭、巨噬细胞功能障碍和细胞衰老等机制逐渐在体内表现出来，显著增加了老年人患病的几率。这些机制相互作用，深刻影响着老年人的生活质量。随着老年人口的持续增长，公共卫生系统的负担预计将会加重。在全球范围内，老年人的肌肉骨骼系统疾病患病率不断上升，导致肢体活动能力下降和痛苦延长。本综述旨在阐明衰老的机制及其相互作用，同时探讨它们对骨关节炎、骨质疏松症和肌肉减少症等疾病的影响。通过深入研究衰老的机制，可以进一步开展预防和减轻其影响的研究，最终目标是减轻未来老年患者的痛苦。
